Why Is a Methadone and Xanax Combination So Dangerous?

For those who may not be familiar with polydrug use, it is a term used to describe the act of consuming more than one drug at the same time. And this can apply to either prescription or street-level drugs. It is also not uncommon for some individuals to combine prescription and street-level drugs when engaging in this type of behavior. Although many people will take part in polydrug use to achieve an intense euphoric high, there are several dangers involved in doing so. For example, when you consume more than one drug at the same time, it not only intensifies the effects of each individual drug but also increases your chances of experiencing severe side effects, some of which can be life-threatening.


While the side effects associated with polydrug use can vary, most individuals will experience one or more of the following:

  • Seizures
  • Ulcers
  • Liver damage
  • Liver failure
  • Respiratory failure
  • Stroke
  • Brain damage
  • Coma

It is also worth noting that polydrug use can potentially deplete dopamine, oxytocin, serotonin, and endorphins in the brain, which can result in behavioral changes, such as the rapid onset of anxiety or depression.


Now that we have a general understanding of the dangers of polydrug use, let’s take a moment to focus on Methadone and Xanax as this combination appears to be growing in popularity. Both of these prescription-based medications are central nervous system depressants, which means that they can slow down brain activity. And when they are combined, this slow down can occur even faster. To better understand how and why this happens, it helps to know a little more about the CNS (central nervous system). The CNS is a network of nerve tissues, which are regulated by the brain and the spinal cord, that control a variety of activities in the body, some of which include

  • Heart rate
  • Breathing
  • Blood pressure
  • Body temperature

When taken as prescribed by a licensed physician, Methadone and Xanax are both safe and can help resolve a wide range of physical and mental health problems, such as chronic pain, anxiety, depression, and panic disorders. However, when they are combined or not taken as prescribed, this is when problems can arise. In nearly all cases, individuals who combine Methadone and Xanax will experience CNS depression, which can trigger many of the side effects detailed in this article. Because combining Methadone and Xanax produces an intense euphoric high, many individuals are not aware of the physiological changes that are taking place in their bodies. And as they start to build up a tolerance, many will increase the dose on one or both medications, which eventually pushes them further into addiction.


When it comes to polydrug use, the best way to break the cycle of addiction is by seeking treatment at a licensed rehab facility. Most of these facilities will recommend an inpatient program for those who are struggling with this form of addiction as they will have access to round-the-clock monitoring and prescription medications to help with detox. And to address the psychological component of one’s polydrug use, most rehab facilities will recommend cognitive behavioral therapy (CBT). This form of behavioral therapy is effective in altering destructive behavioral patterns that often lead to substance abuse. It is also worth noting that CBT, especially when paired with other substance abuse treatments, can significantly improve an individual’s chances of achieving long-term sobriety, according to several studies.


While attending CBT sessions, individuals will work with their therapist to identify underlying issues that may have played a role in their decision to start abusing Methadone and Xanax. They will also learn how to cope with triggers that could potentially result in a relapse. Some of the key areas in which a therapist will focus their efforts as they work toward helping individuals overcome polydrug addiction include

Goal setting – This aspect of CBT involves setting realistic goals that individuals should try to achieve while working to put substance abuse behind them.

Relaxation – This aspect of CBT involves developing strategies to cope with anxiety, depression, cravings, temptation, and stress in a way to promotes a sense of calmness and relaxation.


All in all, polydrug use involving Methadone and Xanax can cause serious health problems and may even be life-threatening. Fortunately, there are treatments available to those who are ready to put this form of substance abuse behind them and better their lives. To learn more about any of the treatments discussed in this article or to start an inpatient treatment program, consider speaking with one of our compassionate associates today at 844-639-8371.

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